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Teratogenic and Cytotoxic activity of Fomitopsis feei collected from Paracelis Mountain Province
(2019) Agana Reyn Dulay
Mushrooms are being utilized by indigenous people and Paracelis Mountain Province is one of the perfect place to search for mushrooms utilized by them. Several studies have been conducted on various macrofungi, however little is known about the Fomitopsis feei collected from Paracelis, Mountain Province. this study determined the teratogenic and cytotoxic activity of the ethanol extract of F. fee against zebrafish (Danio rerio) embryos and brine shrimp (Artemia salina), respectively. The mushroom exhibited teratogenic effects against the developing D. rerio embryos wherein growth reatardation, malformation of tail, yolk deformity, pericardial edema, curved body, scoliosis and lttle pigmentation were the notable teratogenic effects of the ethanol extract to the developing embryos. Embryos treated with ≥1000 ppm recorded high mortality rate. hatchability was most evident at lower concentrations ≤750 ppm. In terms of heartbeat, as the concentration of the extract increased, the heartbeat rate significantly decreased. for the cytotoxicity 1250 ppm has the highest mortality rate with 73.33%. using probit analysis, the LC50 of F. feei is 534.676 ppm which is considered as mildly toxic. Thus, F. feei in highest concentrations exhibit toxic effect.