Theses and Dissertations

Permanent URI for this community

http://granarium.clsu.edu.ph/handle/123456789/2

Browse

Browsing Theses and Dissertations by Subject "Research Subject Categories::TECHNOLOGY::Bioengineering::Plant biotechnology"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Anticancer activity of ethnobotanicals of the ILONGOT-EǴONGOT community of bayanihan, Maria Aurora, Aurora on human colon cancer cells (HCT-116)
    (2019) Earl Jericho DJ. Cachin
    Globally, colon cancer is one of the leading causes of cancer deaths. Colon carcinoma is one of the best-understood neoplasms from the genetic perpective, yet it remains the second most cause of cancer-related deaths. As one of the developing countries, Philippines possess a rich biodiversity that offers wide range of ethnobotanicals waiting to be utilized for cancer treatment. Ethanolic extracts of ten ethnobotanicals were collected from the Ilongot-Eģongot community of Bayanihan, Maria Aurora, Aurora were tested against human colon cancer cell line HCT-116. Cell viability and cytotoxicity was determined using the PrestoBlue® Assay. The assay revealed that Premna odorata Blanco (Local Name: Asedaong; IC₅₀ 0.8747 µg/ml), Dillenia phillippinensis Rolfe (Local Name: Katmon; IC₅₀ 0.6358 µg/ml), Eleusine indica (L.) Gaertn. (Local Name: Pag; IC₅₀ 0.6653 µg/ml), Mikania micrantha L. (Local Name: Ola ola; IC₅₀ 0.8201 µg/ml), Diplazium Esculentum (Retz.) Sw. (Local name: Pako Pako; IC₅₀ 0.7338 µg/ml), Urena lobata L. (Local name: Pukot; IC₅₀ 1.009 µg/ml), Hydrocotyle vulgaris L. (Local name: Gutokola; IC₅₀ 0.8788 µg/ml), Ceiba pentandra (Local name: Betek; IC₅₀ 1.04 µg/ml), Adenanthera intermedia Merr. (Local name: Kares; IC₅₀ 1.295 µg/ml) and Stachytarpheta sp. (Local Name: Luzviminda; IC₅₀ 1.322 µg/ml), showed anticancer activity against human colon cancer cell line (HCT-116). All extract showed an IC₅₀<20 µg/mL which is considered as highly toxic.