Fomitopsis feei (Fr.) is a brown-rot blanket fungus which belongs to the family Fomitopsidaceae. It is characterized with a sessile, effuse -reflexed basidiomata, its color varies from white to pinkish or brown to dark brown. In order to develop a mass cultivation protocol for this mushroom, this study was conducted to determine the optimum conditions for its mycelial growth. The effect of different indigenous culture media and environmental factors such as pH, aeration, illumination and temperature were assessed. The optimum conditions for the secondary mycelial growth of F. feei was luxurious and largest on coconut water gelatin (CWG) medium (83.57 mm) at pH 6.5 (83.13 mm), in sealed (85 mm) dark conditions (85.00 mm) at room temperature (28-32 degress C) (81.96 mm). Moreover, the most abundant mycelial growth is found in cracked corn as spawn material.