Cytotoxic and antibacterial properties of cane toad (Rhinella marina) bufadienolides extract against Salmonella typhimurium and and staphylococcus aureus
| dc.contributor.author | Jan Celso C. Castro | |
| dc.date.accessioned | 2025-10-14T06:07:29Z | |
| dc.date.available | 2025-10-14T06:07:29Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Rhinella marina, a species of toad that are very common in the Philippines possesses bufadienolides which is suspected for having different biological activities like antibacterial activity and cytotoxic activity and in response, a study was conducted to determine the toxicity of the P. marina's posion against Salmonella typhimurium and Staphyloccoccus aureus was also evaluated using the toad's pure bufadienolides and bufadienolides dissolved using hexane as treatments. Cytotoxic analysis of the toad's bufadienolides exhibited an LC50 555.277 ppm which is considered to be light toxic wherein LC50 of 500 tp 1000 ug/ml its classified as light toxic. Pure bufadienolides of R. marina possess light antibacterial activity against S. typhimurium in the first 18 hours of incubation period. Similarly, pure bufadienolides of R. marina showed mild or potent antibacterial activity against S. aureas at 6 hpurs, 12 hours and 18 hours of incubation period. However, Bufadienolides that are dissolved with hexane exhibits a significant decrease in antibacterial activity. | |
| dc.identifier.uri | http://granarium.clsu.edu.ph/handle/123456789/731 | |
| dc.language.iso | en | |
| dc.relation.supervisor | JAY G. MERCULIO, M.Sc. | |
| dc.title | Cytotoxic and antibacterial properties of cane toad (Rhinella marina) bufadienolides extract against Salmonella typhimurium and and staphylococcus aureus | |
| dc.type | Thesis |