Synthesis and antibacterial activity against Staphylococcus aureus and wound healing activities of Allicin-silver nanoparticle composite
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Date
2019
Authors
Louella M. Nuevo.
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Abstract
Allicin extract fresh crushed garlic where synthesized with silver nitrate (AgNo3) and a change in color into dark reddish brown forming allicin-silver nanocomposite and analyzed using UV-Vis Spectroscopy. The MIC of pure allicin and allicin silver nanocomposite were found to be 0.125g/ml using UV-Vis Spectroscopy. The in-vitro bacterial activity of allicin silver nanocomposite against Staphylococcus aureus were tested using disk diffusion assay. Zones of inhibition were measured and the findings were found to be not significantly different between treatments with Streptomycin as the highest zone of inhibition measuring 34.67mm. The in vivo wound healing activity of allicin silver nanocomposite were evaluated using mice (Mus musculus) as the experimental animal. Allicin-silver nanocomposite shows better results with wound healing rate of 95.73% compare to the water with 81.67% wound healing rate.