Teratogenic and Cytotoxic activity of Xylaria papulis collected from Paracelis Mountain Province
| dc.contributor.author | Lois Kristien F. Domingo | |
| dc.date.accessioned | 2025-10-15T07:46:51Z | |
| dc.date.available | 2025-10-15T07:46:51Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Macrofungi is a diverse group of organisms taht have been known to be utilized by ancient people since earliest times for a number of their functions. In the Philippines, macrofungi have been part of the horticultural diversification of the people and have been used by indigenous people across the country. With this being said, Xylaria papulis collected from Paracelis Mountain province have been assessed for its teratogenic and cytotoxic activities. Ethanol extract exhibited teratogenic effects to developing D. rerio embryos. The most notable of these are growth reatardation, and head and tail malformations. Mortality rates of the embryos were significantly high due to exposure to different concentrations of the macrofungi ethanol extract and the hatchability was completed after 48 hours for concentrations ≤250 ppm. Abnormal heart beat rates, as well as pericardial edema causing weak and slow heart beats were noted suggesting defective cardiac function and cardio-toxicity of the extract. Cytotoxicity was observed in all the treatments except for the control with 0% mortality. The highest mean percentage mortality of 90% was recorded in 1250 ppm. Brine shrimp lethality assay also showed an LC50 of 218.507 ppm, which indicates that the extract is highly toxic. | |
| dc.identifier.uri | http://granarium.clsu.edu.ph/handle/123456789/749 | |
| dc.language.iso | en | |
| dc.relation.supervisor | ANGELES M. DE LEON, Ph.D. | |
| dc.title | Teratogenic and Cytotoxic activity of Xylaria papulis collected from Paracelis Mountain Province | |
| dc.type | Thesis |